NEURL4 Polyclonal antibody

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  WB analysis using 55345-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 55345-1-AP (NEURL4 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

NEURL4 Polyclonal Antibody for WB, ELISA

Cat No. 55345-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

Neuralized-like protein 4, Neuralized like protein 4, KIAA1787

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Tested Applications

• Positive WB detected in: HEK-293 cells, HeLa cells, NCI-H1299 cells, U2OS cells

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

55345-1-AP targets NEURL4 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: neuralized homolog 4 (Drosophila)
• Calculated Molecular Weight: 167 kDa
• Observed Molecular Weight: 166 kDa
• GenBank Accession Number: NM_032442
• Gene Symbol: NEURL4
• Gene ID (NCBI): 84461
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q96JN8
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

NEURL4, also known as KIAA1787, has 6 highly conserved neuralized homology repeats (NHRs), which are thought to mediate protein-protein interactions. NEURL4 localizes to the daughter centriole and prevents formation of ectopic microtubule-organizing centers. NEURL4 promotes CCP110 ubiquitination and proteasome-dependent degradation, maintaining normal centrosomal homeostasis and preventing the formation of abnormal microtubule tissue centers (MTOCs) by countering CP110 accumulation(PMID: 22441691, 22261722).