Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
20980-1-AP targets NOD2 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||cow, human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Full Name||nucleotide-binding oligomerization domain containing 2|
|Calculated molecular weight||115 kDa|
|GenBank accession number||NM_022162|
|Gene ID (NCBI)||64127|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
NOD2, also named as CARD15 and IBD1, induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). Defects in NOD2 are a cause of susceptibility to Crohn disease (CD). Defects in NOD2 are a cause of susceptibility to ulcerative colitis. Defects in NOD2 are the cause of early-onset sarcoidosis (EOS). The antibody is specific to NOD2.
Cell Death Dis
NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway.
Vet Immunol Immunopathol
17β-Estradiol and progesterone decrease MDP induced NOD2 expression in bovine mammary epithelial cells.
NOD2-RIP2 contributes to the inflammatory responses of mice in vivo to Streptococcus pneumoniae.
J Oral Pathol Med
The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation.
Biochem Biophys Res Commun
NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy.
Cell Physiol Biochem
NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice.