NOD2 Polyclonal antibody
NOD2 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse and More (2)
Applications
WB, IP, IHC, IF, ELISA
Conjugate
Unconjugated
Cat no : 20980-1-AP
Synonyms
Validation Data Gallery
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Published Applications
KD/KO | See 2 publications below |
WB | See 13 publications below |
IHC | See 7 publications below |
IF | See 5 publications below |
IP | See 1 publications below |
Product Information
20980-1-AP targets NOD2 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Cited Reactivity | human, mouse, rat, bovine |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Peptide |
Full Name | nucleotide-binding oligomerization domain containing 2 |
Calculated Molecular Weight | 115 kDa |
GenBank Accession Number | NM_022162 |
Gene Symbol | NOD2 |
Gene ID (NCBI) | 64127 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
NOD2, also named as CARD15 and IBD1, induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). Defects in NOD2 are a cause of susceptibility to Crohn disease (CD). Defects in NOD2 are a cause of susceptibility to ulcerative colitis. Defects in NOD2 are the cause of early-onset sarcoidosis (EOS). The antibody is specific to NOD2.
Publications
Species | Application | Title |
---|---|---|
Hypertension Novel Role of NOD2 in Mediating Ca2+ Signaling: Evidence From NOD2-Regulated Podocyte TRPC6 Channels in Hyperhomocysteinemia. | ||
J Neuroinflammation NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. | ||
Free Radic Biol Med Identification of NOD2 as a novel target of RNA-binding protein HuR:Evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy. | ||
Biochim Biophys Acta Mol Cell Biol Lipids Effects of peptidoglycan on the development of steatohepatitis. |