NOD2 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 20980-1-AP

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, cow, rat

Positive WB detected in:
Jurkat cells, COLO 320 cells, Jurkat cells

Positive IHC detected in:
human colon tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
nucleotide-binding oligomerization domain containing 2

Calculated molecular weight:
115 kDa

Observed molecular weight:
100-110 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NOD2

Synonyms
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2, NOD2B, PSORAS1
Background

NOD2, also named as CARD15 and IBD1, induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). Defects in NOD2 are a cause of susceptibility to Crohn disease (CD). Defects in NOD2 are a cause of susceptibility to ulcerative colitis. Defects in NOD2 are the cause of early-onset sarcoidosis (EOS). The antibody is specific to NOD2.


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