Product Information
55113-1-PBS targets NPR2 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) |
| Calculated Molecular Weight | 117 kDa |
| Observed Molecular Weight | 111 kDa, 117 kDa |
| GenBank Accession Number | NM_003995 |
| Gene Symbol | NPR2 |
| Gene ID (NCBI) | 4882 |
| RRID | AB_2881270 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P20594 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
NPR2, also named as ANPRB, GC-B, NPR-B, ANPR-B and ANP-B, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It is a receptor for the C-type natriuretic peptide NPPC/CNP hormone. NRP2 has guanylate cyclase activity upon binding of its ligand. It may play a role in the regulation of skeletal growth. NPR2 is the primary receptor for C type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM). The antibody is specific to NPR2.
