NRG1 Polyclonal antibody

NRG1 Polyclonal Antibody for IF, IHC, IP, WB,ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 10527-1-AP


ARIA, GGF, GGF2, Glial growth factor, Heregulin, HGL, HRG, HRG1, HRGA, NDF, Neu differentiation factor, neuregulin 1, NRG1, Pro NRG1, SMDF

Tested Applications

Positive WB detected inhuman liver tissue, mouse liver tissue, SH-SY5Y cells
Positive IP detected inmouse liver tissue
Positive IHC detected inmouse stomach tissue, human stomach tissue, mouse cerebellum tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inMCF-7 cells, HepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

10527-1-AP targets NRG1 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NRG1 fusion protein Ag0803
Full Name neuregulin 1
Calculated molecular weight 32 kDa
Observed molecular weight 55 kDa and 72 kDa
GenBank accession numberBC007675
Gene symbol NRG1
Gene ID (NCBI) 3084
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. NRG1 and its receptor ErbB tyrosine kinase are expressed not only in the developing nervous system, but also in the adult brain.


Product Specific Protocols
WB protocol for NRG1 antibody 10527-1-APDownload protocol
IHC protocol for NRG1 antibody 10527-1-APDownload protocol
IF protocol for NRG1 antibody 10527-1-APDownload protocol
IP protocol for NRG1 antibody 10527-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



ACS Biomater Sci Eng

Sericin Nerve Guidance Conduit Delivering Therapeutically Repurposed Clobetasol for Functional and Structural Regeneration of Transected Peripheral Nerves

Authors - Lei Zhang

Ecotoxicol Environ Saf

Prenatal di-(2-ethylhexyl) phthalate exposure induced myocardial cytotoxicity via the regulation of the NRG1-dependent ErbB2/ErbB4-PI3K/AKT signaling pathway in fetal mice.

Authors - Dongmin Yu

J Exp Clin Cancer Res

miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling.

Authors - Dong-Min Shi

Am J Physiol Renal Physiol

ErbB4 deletion accelerates renal fibrosis following renal injury.

Authors - Fenghua Zeng

Evid Based Complement Alternat Med

Extracellular Vesicle-Encapsulated miR-183-5p from Rhynchophylline-Treated H9c2 Cells Protect against Methamphetamine-Induced Dependence in Mouse Brain by Targeting NRG1.

Authors - Yuting Zhou

Folia Neuropathol

miR-143-3p inhibition promotes neuronal survival in an Alzheimer's disease cell model by targeting neuregulin-1.

Authors - Chengyan Sun