NSUN2 Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 20854-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 31 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293, COLO 320 cells, HeLa cells, HepG2 cells, MCF-7 cells, SH-SY5Y cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human testis tissue

Positive IF detected in:
Hela cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:8000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
NOL1/NOP2/Sun domain family, member 2

Calculated molecular weight:
767aa,86 kDa

Observed molecular weight:
90-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NSUN2

Synonyms
FLJ20303, hTrm4, MISU, NSUN2, SAKI, TRM4
Background

NSUN2, also known as SAKI or Misu (Myc-induced SUN-domain-containing protein) , is a methyltransferase which catalyses (cytosine-5-)-methylation of tRNA. NSUN2 is direct target gene of c-Myc and may act downstream of Myc to regulate epidermal cell growth and proliferation. NSUN2 is overexpressed in various cancer tissues and may be a valuable target for cancer therapy and a cancer diagnostic marker. Recently a splicing mutation in NSUN2 has been identified as the cause of a Dubowitz-like syndrome, an autosomal recessive disorder.


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