Tested Applications
| Positive WB detected in | pig brain tissue, SH-SY5Y cells, PC-12 cells, fetal human brain tissue, rat brain tissue, mouse brain tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
66380-1-Ig targets TrkC in WB, IF, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
| Tested Reactivity | human, mouse, rat, pig |
| Cited Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag2635 Product name: Recombinant human NTRK3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 36-350 aa of BC013693 Sequence: CVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHV Predict reactive species |
| Full Name | neurotrophic tyrosine kinase, receptor, type 3 |
| Calculated Molecular Weight | 839 aa, 94 kDa |
| Observed Molecular Weight | 110 kDa, 160 kDa |
| GenBank Accession Number | BC013693 |
| Gene Symbol | TrkC |
| Gene ID (NCBI) | 4916 |
| RRID | AB_2881756 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q16288 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
TrkC (Tropomyosin Receptor Kinase C), also known as NTRK3 (Neurotrophic Tyrosine Kinase Receptor Type 3), belongs to the Trk family of receptor tyrosine kinases, which also includes TrkA and TrkB. These receptors are primarily involved in the development and function of the nervous system.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for TrkC antibody 66380-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The TrkC Monoclonal antibody (2A7F11), catalog number 66380-1-Ig, has 1 citation. It appears in Bioact Mater (2024), a study on constructing functional neural network tissue using TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair. The cited applications are WB and IF in human samples, placing the research in the fields of neuroscience, neural regeneration, and regenerative medicine.
| Species | Application | Title |
|---|---|---|
Bioact Mater Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair |
Reviews
What customers say
The single review for this antibody reports a 5-star rating from use in immunofluorescence on human brain cortex tissue at a 1:100 dilution. The user noted that NTRK3/TRKC (visualized in green) specifically marked a subtype of astrogliosis in focal cortical dysplasia (FCD) tissue, indicating strong specificity and reliable performance for detecting this target in neural tissue applications.
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
Reyes (Verified Customer) (09-24-2025) | NTRK3 or TRKC (in green) marked mainly a specific subtype of astrogliosis in FCD human tissue
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