Product Information
11592-1-AP targets NUAK2 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag2031 Product name: Recombinant human NUAK2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-303 aa of BC017306 Sequence: MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWV Predict reactive species |
| Full Name | NUAK family, SNF1-like kinase, 2 |
| Calculated Molecular Weight | 628 aa, 70 kDa |
| Observed Molecular Weight | 70 kDa |
| GenBank Accession Number | BC017306 |
| Gene Symbol | NUAK2 |
| Gene ID (NCBI) | 81788 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9H093 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
NUAK2(NUAK family SNF1-like kinase 2) is also named as OMPHK2, SNARK and belongs to the SNF1 subfamily. The function of NUAK2 is partly dependent on anti-apoptotic properties against apoptosis induced by death ligand and NUAK2 also has effects on the migration of cancer cells as speculated from studies on myosin filaments and cytoskeleton organization in normal cells(PMID:21911917). Western blot analysis detected NUAK2 expressed in cancer cell lines of diverse tissue origin(PMID:12409306).
Publications
What published studies show
The anti-NUAK2 antibody (Cat# 11592-1-AP) has 5 total citations. These appear in Cancer Research, Diabetologia, PNAS, Frontiers in Oncology, and Annals of Clinical Biochemistry. The associated research fields span melanoma development and progression, metabolic stress and diabetes regulation of NUAK2/SNARK, tumor growth and migration in melanoma, hepatocellular carcinoma via the NUAK2/NF-κB axis, and cardiovascular disease in systemic lupus erythematosus. Applications cited include WB, IF, and IHC.
| Species | Application | Title |
|---|---|---|
Cancer Res NUAK2 amplification coupled with PTEN deficiency promote melanoma development via CDK activation.
| ||
Diabetologia Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.
| ||
Proc Natl Acad Sci U S A AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma. | ||
Front Oncol Gitogenin impedes tumorigenesis in hepatocellular carcinoma via NUAK2/NF-κB axis. | ||
Ann Clin Biochem Sucrose non-fermenting AMPK related kinase/Pentraxin 3 and DNA damage axis: a gateway to cardiovascular disease in systemic lupus erythematosus among Egyptian patients. |
