Product Information
69501-1-PBS targets IL-6 in ELISA, Non-Neutralization applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | human Humankine IL-6 protein HZ-1019 Predict reactive species |
Full Name | interleukin 6 (interferon, beta 2) |
Gene Symbol | IL6 |
Gene ID (NCBI) | 3569 |
ENSEMBL Gene ID | ENSG00000136244 |
Conjugate | Unconjugated |
Purification Method | Protein G purification |
Storage Buffer | PBS only, pH 7.3. |
Storage Conditions | Store at -80°C. |
Background Information
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
This antibody is a neutralizing control antibody for IL-6, the immunogen is the same as Neutrakine 69001-1-Ig but could not neutralize human IL-6.