• Featured Product
  • KD/KO Validated

OAS3 Polyclonal antibody

OAS3 Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human and More (1)





Cat no : 21915-1-AP


(2 5)oligo(A) synthase 3, 2 5 oligoadenylate synthase 3, 2 5A synthase 3, OAS3, p100, p100 OAS, p100OAS

Tested Applications

Positive WB detected inA375 cells, HeLa cells, human placenta tissue
Positive IHC detected inhuman skin cancer tissue, human brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:4000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)IF : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 21915-1-AP is OAS3 Fusion Protein expressed in E. coli.

Tested Reactivity human
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen OAS3 fusion protein Ag16150
Full Name 2'-5'-oligoadenylate synthetase 3, 100kDa
Calculated Molecular Weight 1087 aa, 121 kDa
Observed Molecular Weight 100-120 kDa
GenBank Accession NumberBC113746
Gene Symbol OAS3
Gene ID (NCBI) 4940
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS3, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). It is also named as p100 OAS and belongs to the 2-5A synthase family. OAS3 is involved in inhibition of cellular protein synthesis and in viral infection resistance. This antibody may have weak cross-reaction with OAS1 protein due to the highly homology.


Product Specific Protocols
WB protocol for OAS3 antibody 21915-1-APDownload protocol
IHC protocol for OAS3 antibody 21915-1-APDownload protocol
IF protocol for OAS3 antibody 21915-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




A prenylated dsRNA sensor protects against severe COVID-19.

Authors - Arthur Wickenhagen
  • KO Validated

Nat Cell Biol

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Authors - Dario F De Jesus

Nat Commun

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.

Authors - Wei Liu

J Invest Dermatol

OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augment Type I Interferon-Induced JAK1-STAT1 Phosphorylation in Psoriasis.

Authors - Yan-Zhou Huang
  • KD Validated

Virol Sin

EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication.

Authors - Xiaolei Zhou
  • KD Validated

Virol Sin

IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway

Authors - Baisong Zheng