OPRD1 Recombinant monoclonal antibody

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• OPRD1 Recombinant monoclonal antibody (87435-1-RR)

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  WB analysis using 87435-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 87435-1-RR (OPRD1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

OPRD1 Uni-rAb^® Recombinant Antibody for WB, ELISA

Cat No. 87435-1-RR

Clone No.252703H3

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Synonyms

D OR 1, Delta type opioid receptor, DOR 1, opioid receptor, delta 1, OPRD

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Tested Applications

• Positive WB detected in: HUVEC cells, U-87 MG cells, Neuro-2a cells

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

87435-1-RR targets OPRD1 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: opioid receptor, delta 1
• Observed Molecular Weight: 45 kDa
• GenBank Accession Number: NM_000911
• Gene Symbol: OPRD1
• Gene ID (NCBI): 4985
• RRID: AB_3745544
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P41143
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Opioid receptor delta 1 (OPRD1), also known as the δ-opioid receptor (DOR), is a class A G protein-coupled receptor (GPCR) that mediates the biological effects of endogenous opioid peptides such as enkephalins. OPRD1 primarily couples to Gi/Go proteins, leading to inhibition of adenylyl cyclase, reduced intracellular cAMP production, modulation of ion channel activity, and suppression of neurotransmitter release. It is widely expressed in the central and peripheral nervous systems, including the cortex, striatum, hippocampus, spinal cord, and sensory neurons, where it regulates analgesia, mood, reward, emotional processing, and neuroprotection. Compared with other opioid receptors, OPRD1 has attracted particular interest as a target for pain management with potentially reduced respiratory depression and abuse liability, although its pharmacology is complex and context dependent. Dysregulated OPRD1 signaling has been implicated in chronic pain, depression, anxiety, addiction, epilepsy, and neuroinflammatory disorders.