PCDH18 Polyclonal antibody

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• PCDH18 Polyclonal antibody (34123-1-AP)

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  IHC staining of human lung using 34123-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 34123-1-AP (PCDH18 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human lung using 34123-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 34123-1-AP (PCDH18 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

PCDH18 Polyclonal Antibody for IHC, ELISA

Cat No. 34123-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, ELISA

Synonyms

KIAA1562, PCDH68L, Protocadherin-18

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Tested Applications

• Positive IHC detected in: human lung tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

34123-1-AP targets PCDH18 in IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag41285

  Product name: Recombinant human PCDH18 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 750-900 aa of BC093815

  Sequence: PSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEG

• Full Name: protocadherin 18
• Calculated Molecular Weight: 1135 aa, 126 kDa
• GenBank Accession Number: BC093815
• Gene Symbol: PCDH18
• Gene ID (NCBI): 54510
• RRID: AB_3743157
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9HCL0
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Protocadherin 18 (PCDH18) is a member of the non-clustered protocadherin subfamily within the cadherin superfamily. Encoded by the PCDH18 gene on chromosome 4q28, it contains six to seven extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail. PCDH18 is expressed in brain, heart, kidney, lung, and trachea. It plays critical roles in cell-cell adhesion, neuronal migration, axon guidance, and synapse formation during development. Emerging evidence links PCDH18 mutations or dysregulation to neurodevelopmental disorders, including autism spectrum disorder and intellectual disability, as well as to certain cancers (PMID: 22450339; PMID: 29075151; PMID: 28588296).