|Positive WB detected in||THP-1 cells, HT-1080 cells, HUVEC cells, U-251 cells|
|Positive FC detected in||THP-1 cells|
|Western Blot (WB)||WB : 1:2000-1:20000|
|Sample-dependent, check data in validation data gallery|
60045-1-Ig targets PDGFRA in WB, IF, FC,ELISA applications and shows reactivity with human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||PDGFRA fusion protein Ag1385|
|Full Name||platelet-derived growth factor receptor, alpha polypeptide|
|Calculated molecular weight||123 kDa|
|Observed molecular weight||100-120 kDa, 140-160 kDa|
|GenBank accession number||BC015186|
|Gene ID (NCBI)||5156|
|Purification Method||Caprylic acid/ammonium sulfate precipitation|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Platelet-derived growth factor receptor alpha (PDGFRA, also known as CD140a) is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGFRA is implicated in the regulation of embryonic development, tumorigenesis, cell proliferation, survival and chemotaxis. Mutations in PDGFRA gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
The vitamin D receptor regulates miR-140-5p and targets the MAPK pathway in bone development.
The long noncoding RNA Meg3 regulates myoblast plasticity and muscle regeneration through epithelial-mesenchymal transition.