PDIA3 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66423-1-Ig |CloneNo.: 3G4G7

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HEK-293 cells, Jurkat cells, RAW 264.7 cells

Recommended dilution:
WB : 1:2000-1:20000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein disulfide isomerase family A, member 3

Calculated molecular weight:
505aa,57 kDa

Observed molecular weight:
57 kDa, 60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PDIA3

Synonyms
58 kDa microsomal protein, Disulfide isomerase ER 60, ER protein 57, ER protein 60, ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PDIA3, PI PLC, Protein disulfide isomerase A3
Background

PDIA3, also named as P58, ER60, ERp57, ERp60, ERp61, GRP57, GRP58 and PI-PLC, is a member of the PDI family, participates in the oxidation, reduction, and isomerization of disulfide bonds for correct folding of secretory proteins before modification and transport in the endoplasmic reticulum. It is associated with apoptosis or inhibition of cancer cell growth. PDIA3 was once thought to be a phospholipase; however, it has been demonstrated that this protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and PDIA3 mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.


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