Product Information
55355-1-AP targets PEAK1 in ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | NKF3 kinase family member |
| Calculated Molecular Weight | 193 kDa |
| GenBank Accession Number | NM_024776 |
| Gene Symbol | PEAK1 |
| Gene ID (NCBI) | 79834 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9H792 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
PEAK1, also named as SGK269 and KIAA2002, belongs to the protein kinase superfamily. (PEAK1). It is a 190-kDa nonreceptor tyrosine kinase that localizes to actin filaments and focal adhesions. PEAK1 undergoes Src-induced tyrosine phosphorylation, regulates the p130Cas-Crk-paxillin and Erk signaling pathways, and operates downstream of integrin and epidermal growth factor receptors (EGFR) to control cell spreading, migration, and proliferation. Perturbation of PEAK1 levels in cancer cells alters anchorage-independent growth and tumor progression in mice. Notably, primary and metastatic samples from colon cancer patients display amplified PEAK1 levels in 81% of the cases. PEAK1 is an important cytoskeletal regulatory kinase and possible target for anticancer therapy. This antibody is specific to PEAK1.
Publications
What published studies show
The PEAK1 Polyclonal antibody (Cat# 55355-1-AP) has 1 citation to date. It appears in iScience (2024), in a study on CXCL3/TGF-β-mediated crosstalk between cancer-associated fibroblasts and tumor cells that augments renal cell carcinoma progression and sunitinib resistance. The associated research field is cancer biology, specifically tumor microenvironment interactions and therapeutic resistance in RCC.
| Species | Application | Title |
|---|---|---|
iScience CXCL3/TGF-β-mediated crosstalk between CAFs and tumor cells augments RCC progression and sunitinib resistance |
