PEX3 Polyclonal antibody, PBS Only

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• PEX3 Polyclonal antibody, PBS Only (10946-1-PBS)

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  WB analysis of HeLa using 10946-1-AP (same clone as 10946-1-PBS)

  WB result of PEX3 antibody (10946-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-PEX3 transfected HeLa cells. This data was developed using the same antibody clone with 10946-1-PBS in a different storage buffer formulation.

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  IF Staining of mouse brain using 10946-1-AP (same clone as 10946-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using PEX3 antibody (10946-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10946-1-PBS in a different storage buffer formulation.

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  IF Staining of mouse kidney using 10946-1-AP (same clone as 10946-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using PEX3 antibody (10946-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10946-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

PEX3 Polyclonal Antibody for WB, IF-P, ELISA

Cat No. 10946-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF-P, ELISA

Synonyms

Peroxin 3, Peroxin-3, PEX

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Product Information

10946-1-PBS targets PEX3 in WB, IF-P, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag1384

  Product name: Recombinant human PEX3 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-228 aa of BC014551

  Sequence: MLRSVWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKIREIQEREAAEYIAQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSTVAVYSTCMLVVLLRVQLNIIGGYIYLDNAAVGKNGTTILAPPDVQQQYLSSIQHLLGDGLTELITVIKQAVQKVLGSVSLKHSLSLLDLEQKLKEIRNLVEQHKSSSWINKD

• Full Name: peroxisomal biogenesis factor 3
• Calculated Molecular Weight: 42 kDa
• Observed Molecular Weight: 42 kDa
• GenBank Accession Number: BC014551
• Gene Symbol: PEX3
• Gene ID (NCBI): 8504
• RRID: AB_2162392
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P56589
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. Peroxin 3, also known as PEX3 (peroxisomal biogenesis factor 3) or TRG18, is a 373 amino acid multi-pass membrane protein that anchored in the peroxisomal membrane and essential for peroxisome biogenesis and integrity. Additionally, Peroxin 3 acts as a docking factor for Peroxin 19 and is required for the import of peroxisomal proteins. Defects in the gene encoding Peroxin 3 are the cause of peroxisome biogenesis disorder complementation group 12 (PBD-CG12) and Zellweger syndrome (ZwS), both of which arise from a failure of peroxisomal protein import.