Product Information
21677-1-PBS targets PLEKHG6 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag15886 Product name: Recombinant human PLEKHG6 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 456-790 aa of BC105961 Sequence: LMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV Predict reactive species |
| Full Name | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 |
| Calculated Molecular Weight | 790 aa, 89 kDa |
| Observed Molecular Weight | 89 kDa |
| GenBank Accession Number | BC105961 |
| Gene Symbol | PLEKHG6 |
| Gene ID (NCBI) | 55200 |
| RRID | AB_3742049 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q3KR16 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
PLEKHG6 is a previously unknown guanine nucleotide exchange factor (GEF) for RhoG. It localizes to the apical membrane of cells, a process that depends on its interaction with the membrane-cytoskeleton linker protein ezrin. This apical localization is essential for inducing morphological changes. Additionally, PLEKHG6 and ezrin are both necessary for macropinocytosis mediated by membrane ruffles. Finally, ezrin facilitates precise spatial regulation of RhoG activation at the apical surface of epithelial cells by recruiting components of the RhoG signaling pathway into a closely associated complex.
