PNMA5 Polyclonal antibody, PBS Only

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• PNMA5 Polyclonal antibody, PBS Only (21770-1-PBS)

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  WB analysis using 21770-1-AP (same clone as 21770-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21770-1-AP (PNMA5 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21770-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse testis using 21770-1-AP (same clone as 21770-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 21770-1-AP (PNMA5 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21770-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse testis using 21770-1-AP (same clone as 21770-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 21770-1-AP (PNMA5 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21770-1-PBS in a different storage buffer formulation.

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  IF Staining of mouse testis using 21770-1-AP (same clone as 21770-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse testis tissue using PNMA5 antibody (21770-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21770-1-PBS in a different storage buffer formulation.

PNMA5 Polyclonal Antibody for WB, IHC, IF-P, Indirect ELISA

Cat No. 21770-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF-P, Indirect ELISA

Synonyms

KIAA1934, paraneoplastic antigen like 5

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Product Information

21770-1-PBS targets PNMA5 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag16414

  Product name: Recombinant human PNMA5 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 133-448 aa of BC101112

  Sequence: SLDAEVMPQVRSPPLEPPKESMWYRKLKVFSGTASPSPGEETFEDWLEQVTEIMPIWQVSEVEKRRRLLESLRGPALSIMRVLQANNDSITVEQCLDALKQIFGDKEDFGASQFRFLQTSPKIGEKVSTFLLRLEPLLQKAVHKSPLSVRSTDMIRLKHLLARVAMTPALRGKLELLDQRGCPPNFLELMKLIRDEEEWENTEAVMKNKEKPSGRGRGASGRQARAEASVSAPQATVQARSFSDSSPQTIQGGLPPLVKRRRLLGSESTRGEDHGQATYPKAENQTPGREGPQAAGEELGNEAGAGAMSHPKPWET

• Full Name: paraneoplastic antigen like 5
• Calculated Molecular Weight: 448 aa, 50 kDa
• Observed Molecular Weight: 50 kDa
• GenBank Accession Number: BC101112
• Gene Symbol: PNMA5
• Gene ID (NCBI): 114824
• RRID: AB_3669374
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q96PV4
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

PNMA5 is a member of the paraneoplastic Ma antigen (PNMA) family proteins which share relatively conserved protein sequences and are involved in the regulation of growth, apoptosis, or fate determination in different cell types (PMID: 29378289). PNMA5 appears to be involved in the association areas of the neocortex during primate evolution (PMID: 19366867). PNMA5 has been reported to play roles in the pathological development and metastasis of some cancers, including colorectal cancer, ovarian cancer, and lung cancer (PMID: 35559417; 35117731; 34136487).