Product Information
19711-1-AP targets POLA1 in WB, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | polymerase (DNA directed), alpha 1, catalytic subunit |
| Calculated Molecular Weight | 166 kDa |
| GenBank Accession Number | NM_016937 |
| Gene Symbol | POLA1 |
| Gene ID (NCBI) | 5422 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P09884 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
POLA1, also named as Pola, belongs to the DNA polymerase type-B family. POLA1 plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1.
Publications
What published studies show
The POLA1 Polyclonal antibody (Cat# 19711-1-AP) has 1 citation, published in Infection and Immunity. The cited study investigated how Pseudomonas aeruginosa triggers macrophage autophagy via NLRP3 inflammasome activation to escape intracellular killing, placing the research in the fields of infectious disease and innate immunity.
| Species | Application | Title |
|---|---|---|
Infect Immun Pseudomonas aeruginosa triggers macrophage autophagy to escape intracellular killing by activating NLRP3 inflammasome. |
