PPIP5K1 Polyclonal antibody, PBS Only

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• PPIP5K1 Polyclonal antibody, PBS Only (14331-1-PBS)

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  WB analysis using 14331-1-AP (same clone as 14331-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 14331-1-AP (PPIP5K1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14331-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skeletal muscle using 14331-1-AP (same clone as 14331-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 14331-1-AP (PPIP5K1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14331-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skeletal muscle using 14331-1-AP (same clone as 14331-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 14331-1-AP (PPIP5K1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14331-1-PBS in a different storage buffer formulation.

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  IF Staining of U-251 using 14331-1-AP (same clone as 14331-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed U-251 cells using PPIP5K1 antibody (14331-1-AP) at dilution of 1:200 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 14331-1-PBS in a different storage buffer formulation.

PPIP5K1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Cat No. 14331-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

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Product Information

14331-1-PBS targets PPIP5K1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag5614

  Product name: Recombinant human HISPPD2A protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-301 aa of BC050263

  Sequence: MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAME

• Full Name: histidine acid phosphatase domain containing 2A
• Calculated Molecular Weight: 160 kDa
• Observed Molecular Weight: 160 kDa
• GenBank Accession Number: BC050263
• Gene Symbol: HISPPD2A
• Gene ID (NCBI): 9677
• RRID: AB_3669185
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q6PFW1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

PPIP5K1 (Inositol diphosphoinositol pentakisphosphate kinase type 1) plays an important role in regulating cell death in response to genotoxic stress. PPIP5K1 act in concert with IP6K2 to promote cell death through controlling localization of stress-activated MAP kinase-interacting protein1 (SIN1) (PMID: 31051014). The activation of the PtdIns 3-kinase pathway is associated with PPIP5K1 translocation from the cytoplasm to the plasma membrane (PMID: 21222653).