• Featured Product
  • KD/KO Validated

PRAME Monoclonal antibody, PBS Only

PRAME Monoclonal Antibody for WB, IF, Indirect ELISA

Host / Isotype

Mouse / IgG2b


Human, mouse, rat


WB, IF, Indirect ELISA





Cat no : 68097-1-PBS


MAPE, OIP 4, OIP4, Opa interacting protein 4, PRAME

Recommended dilution

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

68097-1-PBS targets PRAME in WB, IF, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Reactivity Human, mouse, rat
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen PRAME fusion protein Ag1906
Full Name preferentially expressed antigen in melanoma
Calculated Molecular Weight 509 aa, 58 kDa
Observed Molecular Weight50 kDa
GenBank Accession NumberBC014074
Gene Symbol PRAME
Gene ID (NCBI) 23532
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The PRAME (preferentially expressed antigen of melanoma) gene was previously shown to be overexpressed in ovarian/primary peritoneal serous carcinoma compared with malignant mesothelioma using gene expression arrays. It is considered a melanocyte differentiation antigen which is overexpressed in both solid and hematologic tumors. In normal tissue, a very low level of PRAME expression is found in normal testis, adrenals, ovary and endometrium. A high level of PRAME expression has been reported for several solid tumors, including ovarian cancer, breast cancer, lung cancer and melanomas, medulloblastoma, sarcomas, head and neck cancers, neuroblastoma, renal cancer, and Wilms'tumor. As a nuclear transcriptional repressor protein, PRAME binds to retinoic acid receptor a, thereby inhibiting retinoic acid induced differentiation, growth arrest, and apoptosis.