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  • KD/KO Validated

Presenilin-1-Specific Polyclonal antibody

Presenilin-1-Specific Polyclonal Antibody for IHC, IP, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat, monkey and More (1)





Cat no : 16163-1-AP


AD3, FAD, Presenilin-1, Presenilin-1-Specific, Protein S182, PS 1, PS1, PS1 CTF12, PSEN1, PSNL1, S182

Tested Applications

Positive WB detected inCOS-7 cells, HeLa cells, HepG2 cells, Jurkat cells, rat brain tissue, mouse brain tissue
Positive IP detected inmouse kidney tissue
Positive IHC detected inhuman prostate cancer tissue, mouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:1000-1:8000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

16163-1-AP targets Presenilin-1-Specific in WB, IP, IHC, ELISA applications and shows reactivity with human, mouse, rat, monkey samples.

Tested Reactivity human, mouse, rat, monkey
Cited Reactivityhuman, mouse, rat, pig
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name presenilin 1
Calculated Molecular Weight 53 kDa
Observed Molecular Weight21kDa
GenBank Accession NumberNM_000021
Gene Symbol PSEN1
Gene ID (NCBI) 5663
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome(PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.


Product Specific Protocols
WB protocol for Presenilin-1-Specific antibody 16163-1-APDownload protocol
IHC protocol for Presenilin-1-Specific antibody 16163-1-APDownload protocol
IP protocol for Presenilin-1-Specific antibody 16163-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Adv Sci (Weinh)

Bone Marrow-Derived GCA+ Immune Cells Drive Alzheimer's Disease Progression

Authors - Rui Zhou


MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.

Authors - Bing-Lin Zhu

Cell Rep

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Authors - Yang-Ping Shentu

J Neuroinflammation

Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice.

Authors - Qingyong Li

Cell Commun Signal

Presenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma.

Authors - Wei Yang
  • KD Validated

Mol Neurobiol

Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.

Authors - Yasuteru Inoue


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Xiaoyu (Verified Customer) (02-07-2024)

Good signal

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:1000
  • Cell Tissue Type: brain
Presenilin-1-Specific Antibody Western Blot validation (1:1000 dilution) in brain (Cat no:16163-1-AP)