- Featured Product
- KD/KO Validated
Presenilin-1-Specific Polyclonal antibody
Presenilin-1-Specific Polyclonal Antibody for IHC, IP, WB,ELISA
Cat no : 16163-1-AP
|Positive WB detected in||human kidney tissue|
|Positive IP detected in||mouse kidney tissue|
|Positive IHC detected in||human gliomas tissue, mouse brain tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:3000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
16163-1-AP targets Presenilin-1-Specific in WB, IP, IHC,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, pig, rat|
|Host / Isotype||Rabbit / IgG|
|Full Name||presenilin 1|
|Calculated molecular weight||53 kDa|
|Observed molecular weight||53 kDa|
|GenBank accession number||NM_000021|
|Gene ID (NCBI)||5663|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome(PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.
|Product Specific Protocols|
|WB protocol for Presenilin-1-Specific antibody 16163-1-AP||Download protocol|
|IHC protocol for Presenilin-1-Specific antibody 16163-1-AP||Download protocol|
|IP protocol for Presenilin-1-Specific antibody 16163-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells.
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Cell Death Discov
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease.
Cell Biol Int
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.
Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.