- Featured Product
- KD/KO Validated
Securin Polyclonal antibody
Securin Polyclonal Antibody for IF, WB, ELISA
Host / Isotype
Rabbit / IgG
Human and More (2)
WB, IHC, IF, ELISA
Cat no : 18040-1-AP
|Positive WB detected in||Daudi cells, HepG2 cells, MDA-MB-231 cells|
|Positive IF detected in||HepG2 cells|
|Western Blot (WB)||WB : 1:1000-1:6000|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
|KD/KO||See 1 publications below|
|WB||See 3 publications below|
|IHC||See 1 publications below|
|IF||See 3 publications below|
18040-1-AP targets Securin in WB, IHC, IF, ELISA applications and shows reactivity with Human samples.
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Securin fusion protein Ag12670|
|Full Name||pituitary tumor-transforming 1|
|Calculated molecular weight||202 aa, 22 kDa|
|Observed molecular weight||28 kDa|
|GenBank accession number||BC101834|
|Gene ID (NCBI)||9232|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Securin, also known as the pituitary tumor transforming gene (PTTG1), was first isolated from rat pituitary tumor cells. Securin is a multi-functional protein that regulates sister chromatin segregation in mitosis, DNA repair, gene transcription, metabolism, and organ development. Securin is normally expressed in tissues with high proliferative activity, including the spleen, thymus gland, and testis, whereas it is rarely expressed in differentiated mature tissues (PMID: 22563433, PMID: 36123907). The calculated molecular weight of Securin is 22 kDa. With post-translational modification, the molecular weight of Securin will be migrated to 28 kDa.
|Product Specific Protocols|
|WB protocol for Securin antibody 18040-1-AP||Download protocol|
|IF protocol for Securin antibody 18040-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Cell Mol Life Sci
Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.
APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.
Melatonin promotes in vitro maturation of vitrified-warmed mouse GV oocytes potentially by modulating MAD2 protein expression of SAC component through MTRs.
Open Med (Wars)
The Pseudogene PTTG3P Promotes Cell Migration and Invasion in Esophageal Squamous Cell Carcinoma.
Chronic restraint stress disturbs meiotic resumption through APC/C-mediated cyclin B1 excessive degradation in mouse oocytes.