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  • KD/KO Validated

Securin Polyclonal antibody

Securin Polyclonal Antibody for IF, WB, ELISA

Host / Isotype

Rabbit / IgG


Human and More (2)





Cat no : 18040-1-AP


EAP1, Esp1 associated protein, HPTTG, pituitary tumor transforming 1, PTTG, PTTG1, Securin, Securin / PTTG1, Tumor transforming protein 1, TUTR1

Tested Applications

Positive WB detected inDaudi cells, HepG2 cells, MDA-MB-231 cells
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:6000
Immunofluorescence (IF)IF : 1:10-1:100
Sample-dependent, check data in validation data gallery

Product Information

18040-1-AP targets Securin in WB, IHC, IF, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Securin fusion protein Ag12670
Full Name pituitary tumor-transforming 1
Calculated molecular weight 202 aa, 22 kDa
Observed molecular weight28 kDa
GenBank accession numberBC101834
Gene symbol PTTG1
Gene ID (NCBI) 9232
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Securin, also known as the pituitary tumor transforming gene (PTTG1), was first isolated from rat pituitary tumor cells. Securin is a multi-functional protein that regulates sister chromatin segregation in mitosis, DNA repair, gene transcription, metabolism, and organ development. Securin is normally expressed in tissues with high proliferative activity, including the spleen, thymus gland, and testis, whereas it is rarely expressed in differentiated mature tissues (PMID: 22563433, PMID: 36123907). The calculated molecular weight of Securin is 22 kDa. With post-translational modification, the molecular weight of Securin will be migrated to 28 kDa.


Product Specific Protocols
WB protocol for Securin antibody 18040-1-APDownload protocol
IF protocol for Securin antibody 18040-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Cell Mol Life Sci

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

Authors - Kyoung-In Cho

Sci Rep

APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.

Authors - Mengchen Zhang


Melatonin promotes in vitro maturation of vitrified-warmed mouse GV oocytes potentially by modulating MAD2 protein expression of SAC component through MTRs.

Authors - Jinyu Yang

Open Med (Wars)

The Pseudogene PTTG3P Promotes Cell Migration and Invasion in Esophageal Squamous Cell Carcinoma.

Authors - Zhenhua Zhang
  • KD Validated

Cell Cycle

Chronic restraint stress disturbs meiotic resumption through APC/C-mediated cyclin B1 excessive degradation in mouse oocytes.

Authors - Junyan Sun