PYCR1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66510-1-Ig |CloneNo.: 1H2G1

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Con: 150 μg/150 μl

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Species specificity:
Human, mouse, rat

Positive WB detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:6000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
pyrroline-5-carboxylate reductase 1

Calculated molecular weight:
319aa,33.8 kDa

Observed molecular weight:
33 kDa, 35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PYCR1

Synonyms
P5C, P5C reductase 1, P5CR, P5CR 1, PIG45, PP222, PYCR, PYCR1
Background

PYCR1,also named as P5CR1, belongs to the pyrroline-5-carboxylate reductase family. It is a housekeeping enzyme that catalyzes the last step in proline biosynthesis. PYCR1 can utilize both NAD and NADP, but has higher affinity for NAD. It is involved in the cellular response to oxidative stress. Mutation in PYCR1 will cause ARCL type II(ARCL2B ). Some mutation will cause DeBarsy syndrome (DBS) which is characterized by progeroid features, ophthalmological abnormalities, intrauterine growth retardation, and cutis laxa.


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