Phospho-APP (Thr668) Polyclonal antibody, PBS Only

• 

  WB analysis using 28788-1-AP (same clone as 28788-1-PBS)

  Non-treated and nocodazole treated SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 28788-1-AP (Phospho-APP (Thr668) antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28788-1-PBS in a different storage buffer formulation.

Phospho-APP (Thr668) Polyclonal Antibody for WB, Indirect ELISA

Cat No. 28788-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

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Product Information

28788-1-PBS targets Phospho-APP (Thr668) in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: amyloid beta (A4) precursor protein
• Observed Molecular Weight: 110 kDa
• GenBank Accession Number: BC065529
• Gene Symbol: APP
• Gene ID (NCBI): 351
• RRID: AB_2918202
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P05067
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Amyloid precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain(PMID: 25719338). APP is expressed in many tissues and concentrated in the synapses of neurons. The molecular weight of APP is 100-140 kDa due to the existence of several isoforms. The phosphorylation of APP at Thr668 is involved in the pathogenesis of Alzheimer's disease (AD). The Phospho-APP Thr668 form is neuron‐specific, highly expressed in dystrophic neurites and amyloid plaques of Alzheimer disease, and induces neurodegeneration(PMID: 27076121).