Product Information
87795-3-PBS targets Phospho-Beta Arrestin 1 (Ser412) in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | arrestin, beta 1 |
| Calculated Molecular Weight | 47 kDa |
| Observed Molecular Weight | 50 kDa |
| GenBank Accession Number | NM_004041 |
| Gene Symbol | Beta Arrestin 1 |
| Gene ID (NCBI) | 408 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P49407 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
β-Arrestins (ARRBs), the best known regulators of G protein-coupled receptor signaling, are versatile and multifunctional adapter proteins that regulate diverse cellular functions, including cell growth, apoptosis and immune responses. Phospho‑β‑arrestin 1 (Ser412) is a key phosphorylated isoform of β‑arrestin 1. Its Ser412 residue is mainly phosphorylated by ERK, governing GPCR desensitization, receptor internalization and downstream signal transduction. This modification regulates β‑arrestin 1 subcellular localization and scaffold function, participating in cell proliferation and insulin‑related ERK signaling desensitization as a vital negative feedback regulator. (PMID: 10347142, PMID: 15520010)
