Product Information
87312-1-PBS targets Phospho-P53 (Ser33) in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | tumor protein p53 |
| Calculated Molecular Weight | 44 kDa |
| Observed Molecular Weight | 53 kDa |
| GenBank Accession Number | NM_000546 |
| Gene Symbol | P53 |
| Gene ID (NCBI) | 7157 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P04637 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
TP53, also known as P53 and NY-CO-13, belongs to the p53 family and has 9 isoforms. In SDS-Page, the observed molecular weight is about 53 kDa. Phosphorylation of p53 at specific amino acid residues plays a crucial role in mediating its various functions, including its role as a transcription factor that regulates the expression of genes involved in the cellular response to stress and DNA damage. Upon severe DNA damage, p53 is phosphorylated at specific amino acid residues, becomes stabilized, and activated to induce apoptosis-related genes. To date, 10 kinases have been identified to phosphorylate p53 for apoptosis at specific serine/threonine residues in the N- and C-terminus domains. (PMID: 30191640)
