Phospho-XIAP (Ser87) Polyclonal antibody
Phospho-XIAP (Ser87) Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Human, mouse, rat
Cat no : 28791-1-AP
|Positive WB detected in
|PDGF treated NIH/3T3 cells
|Western Blot (WB)
|WB : 1:1000-1:6000
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
28791-1-AP targets Phospho-XIAP (Ser87) in WB, ELISA applications and shows reactivity with Human, mouse, rat samples.
|Human, mouse, rat
|Host / Isotype
|Rabbit / IgG
|X-linked inhibitor of apoptosis
|Calculated molecular weight
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
XIAP, also named as API3, BIRC4 and IAP3, belongs to the IAP family. It has E3 ubiquitin-protein ligase activity. It mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells. XIAP is directly phosphorylated by PKC and that XIAP phosphorylated at Ser87 by PKC is resistant to degradation, protecting cells from apoptosis-inducing stress.