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p107 Polyclonal antibody

p107 Polyclonal Antibody for WB, IP, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat and More (1)





Cat no : 13354-1-AP


CP107, p107, PRB1, RBL1, retinoblastoma like 1 (p107), Retinoblastoma like protein 1

Tested Applications

Positive WB detected inmouse testis tissue, COLO 320 cells
Positive IP detected inmouse testis tissue

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

13354-1-AP targets p107 in WB, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, non-human primate
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen p107 fusion protein Ag4146
Full Name retinoblastoma-like 1 (p107)
Calculated Molecular Weight 1068 aa, 119 kDa
Observed Molecular Weight 119 kDa
GenBank Accession NumberBC032247
Gene Symbol RBL1
Gene ID (NCBI) 5933
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Retinoblastoma-like protein 1, also named RBL1, p107, is a member of E1A-binding proteins, which contains a A/B pocket, or pRb. Via this structure, RBL1 can bind to viral oncoproteins and other perteins containing LXCXE motif. It regulates cell proliferation via phosphorylation-sensitive interactions with E2F transcription factors and other proteins. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression.(uniprot). It has been reported there are two transcirpts variants of RBL1, which encode a 119-kd protein and a 68-kd protein(PMID:7490090).


Product Specific Protocols
WB protocol for p107 antibody 13354-1-APDownload protocol
IP protocol for p107 antibody 13354-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Commun

p107 mediated mitochondrial function controls muscle stem cell proliferative fates.

Authors - Debasmita Bhattacharya

Cancers (Basel)

RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways.

Authors - Elisa Ventura

Front Cell Dev Biol

miR-29b-3p Increases Radiosensitivity in Stemness Cancer Cells via Modulating Oncogenes Axis

Authors - Dong Pan


Methylation of promoter of RBL1 enhances the radioresistance of three dimensional cultured carcinoma cells.

Authors - Dong Pan
  • KD Validated

Biochem Pharmacol

Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms.

Authors - Ji Young Kim

Mol Pharm

Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.

Authors - Xiaoman Chen