Product Information
19908-1-PBS targets RGP1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag13902 Product name: Recombinant human RGP1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-391 aa of BC001725 Sequence: MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPDSQTVFLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPIEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLAELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGVPSVSHVTHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPTTWTGPEQVPVDTFSWDLPIKVLPTSPTLASYAAPGPSTSTITI Predict reactive species |
| Full Name | RGP1 retrograde golgi transport homolog (S. cerevisiae) |
| Calculated Molecular Weight | 391 aa, 42 kDa |
| Observed Molecular Weight | 42 kDa |
| GenBank Accession Number | BC001725 |
| Gene Symbol | RGP1 |
| Gene ID (NCBI) | 9827 |
| RRID | AB_3741972 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q92546 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
The RGP1 protein (also known as KIAA0258 or RAB6A-GEF complex chaperone protein 2) belongs to the RGP1 protein family and serves as a core component of the RIC1-RGP1 complex. It functions as a guanine nucleotide exchange factor (GEF) by specifically binding to and activating the small GTPase RAB6A (promoting its conversion from the GDP-bound inactive state to the GTP-bound active state), thereby regulating the retrograde transport of endocytosis-derived vesicles from late endosomes to the Golgi apparatus and participating in the recycling of the mannose-6-phosphate receptor. It plays a critical role in maintaining Golgi structure and function, as well as in regulating intracellular protein trafficking.
