RGS2 Polyclonal antibody

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• KD/KO Validated

RGS2 Polyclonal Antibody for WB, IHC, ELISA

Cat No. 10678-1-AP Copied!

Publications (11)

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Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, IP, ELISA

Synonyms

G0S8, Cell growth inhibiting gene 31 protein, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, GIG31

• 

  WB analysis of fetal human brain using 10678-1-AP

  fetal human brain tissue were subjected to SDS PAGE followed by western blot with 10678-1-AP (RGS2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis of human brain using 10678-1-AP

  human brain tissue were subjected to SDS PAGE followed by western blot with 10678-1-AP (RGS2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human pancreas cancer using 10678-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 10678-1-AP (RGS2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of mouse bladder using 10678-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse bladder tissue slide using 10678-1-AP (RGS2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of mouse bladder using 10678-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse bladder tissue slide using 10678-1-AP (RGS2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of mouse pancreas using 10678-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 10678-1-AP (RGS2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of rat bladder using 10678-1-AP

  Immunohistochemical analysis of paraffin-embedded rat bladder tissue slide using 10678-1-AP (RGS2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of rat pancreas using 10678-1-AP

  Immunohistochemical analysis of paraffin-embedded rat pancreas tissue slide using 10678-1-AP (RGS2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of rat adrenal gland using 10678-1-AP

  Immunohistochemical analysis of paraffin-embedded rat adrenal gland tissue slide using 10678-1-AP (RGS2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: fetal human brain tissue, human brain tissue
• Positive IHC detected in: human pancreas cancer tissue, mouse bladder tissue, mouse pancreas tissue, rat adrenal gland tissue, rat bladder tissue, rat pancreas tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000
• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

10678-1-AP targets RGS2 in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag1066

  Product name: Recombinant human RGS2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-211 aa of BC007049

  Sequence: MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT

• Full Name: regulator of G-protein signaling 2, 24kDa
• Calculated Molecular Weight: 24 kDa
• Observed Molecular Weight: 24-30 kDa
• GenBank Accession Number: BC007049
• Gene Symbol: RGS2
• Gene ID (NCBI): 5997
• RRID: AB_2284998
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P41220
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Publications

What published studies show

The anti-RGS2 antibody (Cat# 10678-1-AP) has 11 total citations published in journals including J Clin Invest, Biomaterials, Basic Res Cardiol, Respir Res, J Chem Inf Model, Ecotoxicol Environ Saf, Bioorg Chem, J Cell Physiol, Toxicol Appl Pharmacol, Virology, and Hum Mutat. Research fields span cancer biology (dormancy, NSCLC, prostate and hepatocellular carcinoma), cardiovascular disease, pulmonary fibrosis, ovarian injury, macrophage protection, and viral infection.

Automatically generated from the 11 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human	WB	J Clin Invest; RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse.; Authors - Jaebeom Cho ; KD Validated
human	IF	Biomaterials; Modeling calcific aortic valve disease with engineered human valve tissues identifies SAMHD1 as a therapeutic target.; Authors - Xiangfu Meng
human	WB	Basic Res Cardiol; Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.; Authors - Klaiber Michael M
rat	WB,IP	Ecotoxicol Environ Saf; Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca2 + ]i stability; Authors - Zhenhua Ma
human	WB	J Chem Inf Model; In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity; Authors - Adam Bair
human	WB	Respir Res; Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.; Authors - Yan Xie