RNF41 Recombinant monoclonal antibody, PBS Only

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• RNF41 Recombinant monoclonal antibody, PBS Only (88043-1-PBS)

RNF41 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 88043-1-PBS

Clone No.253576H1

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

E3 ubiquitin-protein ligase NRDP1, EC:2.3.2.27, FLRF, NRDP1, RING finger protein 41

• 

  WB analysis using 88043-1-RR (same clone as 88043-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 88043-1-RR (RNF41 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 88043-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

88043-1-PBS targets RNF41 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Ag11076

  Product name: Recombinant human RNF41 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-317 aa of BC032637

  Sequence: MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI

• Full Name: ring finger protein 41
• Calculated Molecular Weight: 317 aa, 36 kDa
• Observed Molecular Weight: 35-40 kDa
• GenBank Accession Number: BC032637
• Gene Symbol: RNF41
• Gene ID (NCBI): 10193
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9H4P4
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

RNF41 acts as an E3 ubiquitin ligase to promote ErbB3 ubiquitination and degradation in cultured cells through its RING finger domain (PMID: 12411582). RNF41 acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of the intracellular redox state (PMID: 18541373).