RORC Polyclonal antibody

RORC Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

WB, IHC, ChIP, ELISA

Conjugate

Unconjugated

Cat no : 13205-1-AP

Synonyms

NR1F3, Nuclear receptor ROR gamma, Nuclear receptor RZR gamma, Nuclear receptor RZR-gamma, RAR related orphan receptor C, ROR gamma T, RORC, RORG, RORyT, RORγt, RZR GAMMA, RZRG, TOR



Tested Applications

Positive WB detected inHEK-293 cells, Jurkat cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Sample-dependent, check data in validation data gallery

Product Information

13205-1-AP targets RORC in WB, IHC, ChIP, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat, chicken
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen RORC fusion protein Ag3961
Full Name RAR-related orphan receptor C
Calculated molecular weight 518 aa, 58 kDa
Observed molecular weight 58 kDa
GenBank accession numberBC031554
Gene symbol RORC
Gene ID (NCBI) 6097
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

The Nuclear receptors retinoic acid receptor-related orphan receptor gamma (RORγ or RORc, also known as NR1F3) was the third and most recent ROR group member to be discovered, following the prior disclosures of RORα (RORa or NR1F1) and RORβ (RORb or NR1F2) (PMID:24502334). Studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2.RORC has 2 isoforms with the MW of 56 kDa and 58 kDa.

Protocols

Product Specific Protocols
WB protocol for RORC antibody 13205-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB,ChIP

Oncogene

Targeting the cholesterol-RORα/γ axis inhibits colorectal cancer progression through degrading c-myc

Authors - Ying-Nan Wang
ratWB

Biomed Pharmacother

Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.

Authors - Yu Xia
ratWB

Phytomedicine

Extracts of Poria cocos improve functional dyspepsia via regulating brain-gut peptides, immunity and repairing of gastrointestinal mucosa

Authors - Yijun Tu
mouseWB

Food Funct

Folic acid intervention changes liver Foxp3 methylation and ameliorates the damage caused by Th17/Treg imbalance after long-term alcohol exposure.

Authors - Huichao Zhao
mouseWB

J Ethnopharmacol

The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation.

Authors - Man Zhang
mouseWB

Int Immunopharmacol

Baicalin suppresses Th1 and Th17 responses and promotes Treg response to ameliorate sepsis-associated pancreatic injury via the RhoA-ROCK pathway.

Authors - Pingping Liu