|Positive WB detected in||MCF-7 cells|
|Positive IHC detected in||human oesophagus cancer tissue, human breast cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:200-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
13061-1-AP targets S100A7/Psoriasin in WB, IHC,ELISA applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Immunogen||S100A7/Psoriasin fusion protein Ag3738|
|Full Name||S100 calcium binding protein A7|
|Calculated molecular weight||101 aa, 11 kDa|
|Observed molecular weight||11 kDa|
|GenBank accession number||BC034687|
|Gene ID (NCBI)||6278|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
S100A7 (psoriasin), a member of the S100 protein family, is a well-known antimicrobial peptide and a signaling molecule which regulates cellular function and is expressed in many squamous cell carcinomas (SCCs), such as SCC of the skin. It is an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities.
Mol Med Rep
TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes.
PSMC2, ORC5 and KRTDAP are specific biomarkers for HPV-negative head and neck squamous cell carcinoma.
Cell Biol Int
S100A7 promotes the development of human endometriosis by activating NF-κB signaling pathway in endometrial stromal cells.