SCARF1 Polyclonal antibody

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• KD/KO Validated

SCARF1 Polyclonal Antibody for WB, ELISA

Cat No. 13702-1-AP Copied!

Publications (6)

Download datasheet

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

WB, IF, ELISA

Synonyms

Acetyl LDL receptor, KIAA0149, Scavenger receptor class F member 1, Scavenger receptor expressed by endothelial cells 1, SREC

• 

  WB analysis using 13702-1-AP

  mouse lung tissue and unboiled mouse lung tissue were subjected to SDS PAGE followed by western blot with 13702-1-AP (SCARF1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: mouse lung tissue, unboiled mouse lung tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

13702-1-AP targets SCARF1 in WB, IF, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag4621

  Product name: Recombinant human SCARF1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 438-830 aa of BC039735

  Sequence: LACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPDEAEAPESFPAAASPGDSATGHRRPPLGSRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP

• Full Name: scavenger receptor class F, member 1
• Calculated Molecular Weight: 830 aa, 87 kDa
• Observed Molecular Weight: 90 kDa
• GenBank Accession Number: BC039735
• Gene Symbol: SCARF1
• Gene ID (NCBI): 8578
• RRID: AB_2182983
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q14162
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Scavenger receptor class F member 1 (SCARF1), also known as scavenger receptor expressed by endothelial cells (SREC)-I, belongs to the scavenger receptor (SR) superfamily. SCARF1 has been shown to bind modified low density lipoproteins (LDLs), including acetylated (Ac-) and oxidized (ox-) LDLs (PMID: 29725698; PMID: 15145948). In addition to binding and internalizing a diverse range of endogenous proteins, SCARF1 also binds a wide array of viral, fungal, and bacterial antigens (PMID: 29242513). SCARF1 has a calculated molecular weight of 87 kDa, with a molecular weight of 140-160 kDa due to N-glycosylation (PMID: 22279061; PMID: 15145948). SCARF1 can also exist as a dimer (~ 180 kDa) and a truncated soluble form (~ 60 kDa) (PMID: 29242513; PMID: 29725698).

Publications

What published studies show

The anti-SCARF1 antibody (Cat# 13702-1-AP) has 6 total citations. These appear in Nature Immunology, Cell Reports, Cell Proliferation, Frontiers in Immunology, Journal of Investigative Dermatology, and Journal of Developmental Biology. Research fields span immunology (apoptotic cell clearance, autoimmunity, complement/sepsis), oncology (tumor-associated macrophages, lung adenocarcinoma), liver transplantation, dermatology (vitiligo/ferroptosis), and developmental biology (haematopoietic progenitors).

Automatically generated from the 6 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
mouse	IF	Nat Immunol; The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity.; Authors - Ramirez-Ortiz Zaida G ZG ; KO Validated
mouse		Cell Rep; Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.; Authors - Tamihiro Kamata
rat	WB	Cell Prolif; SCARF1 promotes M2 polarization of Kupffer cells via calcium-dependent PI3K-AKT-STAT3 signalling to improve liver transplantation.; Authors - Xue-Song Xu
		J Invest Dermatol; Heat shock protein 70/toll-like receptor 2 orchestrates melanocyte ferroptosis in the onset of vitiligo.; Authors - Xiaoxue Xing
human		Front Immunol; Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality; Authors - Alissa Trzeciak
mouse	IF	J Dev Biol; Discovery of New Markers for Haemogenic Endothelium and Haematopoietic Progenitors in the Mouse Yolk Sac.; Authors - Guillermo Diez-Pinel