|Positive WB detected in||HepG2 cells, human liver tissue, mouse liver tissue, rat liver tissue|
|Positive IHC detected in||human breast cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:1000-1:5000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
14575-1-AP targets SDHC in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||SDHC fusion protein Ag5775|
|Full Name||succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa|
|Calculated molecular weight||19 kDa|
|Observed molecular weight||15 kDa|
|GenBank accession number||BC033626|
|Gene ID (NCBI)||6391|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
SDHC(Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is also named as CYB560, SDH3 and belongs to the cytochrome b560 family. It is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHC are the cause of paragangliomas type 3 (PGL3) and paraganglioma and gastric stromal sarcoma (PGGSS). It has a transit peptide of 29 amino acid and has 5 isoforms produced by alternative splicing.
Quantitative proteomics in A30P*A53T α-synuclein transgenic mice reveals upregulation of Sel1l.
Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver.
Nucleic Acids Res
Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice.
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.