Anti-Human SEMA7A Rabbit Recombinant Antibody, PBS Only

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• Anti-Human SEMA7A Rabbit Recombinant Antibody, PBS Only (98324-3-PBS)

SEMA7A Uni-rAb^® Recombinant Antibody for FC

Cat No. 98324-3-PBS

Clone No.241814B12

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD108, CDw108, John-Milton-Hargen human blood group Ag, Sema K1, Sema L

• 

  FC experiment of human PBMCs using 98324-3-RR (same clone as 98324-3-PBS)

  1x10^6 untreated or PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human SEMA7A Rabbit RecAb (98324-3-RR, Clone: 241814B12) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98324-3-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  FC experiment of human PBMCs using 98324-3-RR (same clone as 98324-3-PBS)

  1x10^6 PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human SEMA7A Rabbit RecAb (98324-3-RR, Clone: 241814B12) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human SEMA7A Rabbit RecAb (98324-3-RR, Clone: 241814B12) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98324-3-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

98324-3-PBS targets SEMA7A in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg2005

  Product name: Recombinant Human SEMA7A protein (rFc Tag)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 45-648 aa of NM_003612.5

  Sequence: QGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALA

• Full Name: semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
• Calculated Molecular Weight: 75kDa
• GenBank Accession Number: NM_003612.5
• Gene Symbol: SEMA7A
• Gene ID (NCBI): 8482
• RRID: AB_3745975
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: O75326-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SEMA7A, also named CD108 and SEMAL, belongs to the semaphorin family. SEMA7A is the only membrane-associated glycosylphosphatidylinositol (GPI)-linked semaphorin and plays a role in the regulation of neuronal axon outgrowth. In addition to its role in guiding axon pathfinding during neuronal development, SEMA7A has diverse functions in morphogenesis and immune cell control and regulates T cell responses via the α1β1 integrin receptor.