Product Information
13707-1-PBS targets SEPT12 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag4644 Product name: Recombinant human SEPT12 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-358 aa of BC035619 Sequence: MDPLRRSPSPCLSSQPSSPSTPPCEMLGPVGIEAVLDQLKIKAMKMGFEFNIMVVGQSGLGKSTMVNTLFKSKVWKSNPPGLGVPTPQTLQLHSLTHVIEEKGVKLKLTVTDTPGFGDQINNDNCWDPILGYINEQYEQYLQEEILITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLQRLCRTVNVVPVIARADSLTMEEREAFRRRIQQNLRTHCIDVYPQMCFDEDINDKILNSKLRDRIPFAVVGADQEHLVNGRCVLGRKTKWGIIEVENMAHCEFPLLRDLLIRSHLQDLKDITHNIHYENYRVIRLNESHLLPRGPGWVNLAPASPGQLTTPRTFKVCRGAHDDSDDEF Predict reactive species |
| Full Name | septin 12 |
| Calculated Molecular Weight | 358 aa, 41 kDa |
| Observed Molecular Weight | 41 kDa |
| GenBank Accession Number | BC035619 |
| Gene Symbol | SEPT12 |
| Gene ID (NCBI) | 124404 |
| RRID | AB_3741840 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8IYM1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
SEPT12, also known as Septin 12, SPGF10, is a member of the Septin GTPase family. The Septin family is a group of evolutionarily conserved GTP-binding proteins involved in various cellular processes. SEPT12 is a cytoskeletal GTPase that is specifically enriched in the testis. It plays a critical role in spermatogenesis, particularly in the formation and maintenance of sperm tail structures. Mutations or downregulation of SEPT12 have been linked to male infertility due to defects in sperm morphology and function(PMID: 30513371).
