Product Information
33589-1-PBS targets SFRS15 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37951 Product name: Recombinant human SFRS15 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 991-1147 aa of BC064990 Sequence: FNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSAAEAPR Predict reactive species |
| Full Name | splicing factor, arginine/serine-rich 15 |
| Observed Molecular Weight | 150 kDa |
| GenBank Accession Number | BC064990 |
| Gene Symbol | SFRS15 |
| Gene ID (NCBI) | 57466 |
| RRID | AB_3743022 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | O95104 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
SCAF4 is an mRNA anti-terminator protein that plays a crucial role in regulating transcription by RNA Polymerase II. It functions by binding to the phosphorylated CTD of Pol II and interacting with splicing factors to suppress premature transcription termination, particularly at genes with complex structures. This activity ensures proper transcriptional readthrough and full-length mRNA production, thereby influencing gene expression critical for cellular homeostasis. Dysregulation of SCAF4-mediated anti-termination is implicated in disrupted mRNA processing and potential disease states.
