SNX2 Polyclonal antibody

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• SNX2 Polyclonal antibody (11737-1-AP)

• 

  WB analysis of HEK-293 using 11737-1-AP

  WB result of SNX2 antibody (11737-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SNX2 transfected HEK-293 cells.

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  WB analysis using 11737-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 11737-1-AP (SNX2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

• KD/KO Validated

SNX2 Polyclonal Antibody for WB, ELISA

Cat No. 11737-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Synonyms

Sorting nexin-2, Transformation-related gene 9 protein, TRG9, TRG-9

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Tested Applications

• Positive WB detected in: HEK-293 cells, HeLa cells, NIH/3T3 cells, mouse spleen tissue

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

11737-1-AP targets SNX2 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag2259

  Product name: Recombinant human SNX2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 171-520 aa of BC003382

  Sequence: SMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA

• Full Name: sorting nexin 2
• Calculated Molecular Weight: 519 aa, 58 kDa
• Observed Molecular Weight: ~70 kda
• GenBank Accession Number: BC003382
• Gene Symbol: SNX2
• Gene ID (NCBI): 6643
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O60749
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Sorting nexin 2 (SNX2) belongs to the sorting nexin family, characterized by the presence of a phox (PX) domain that binds phosphoinositides and mediates intracellular trafficking. It regulates the cell-surface expression and degradation of epidermal growth factor receptor (EGFR) through endosomal sorting (PMID: 14978220). SNX2 also participates in retrograde transport from endosomes to the trans-Golgi network and maintains cellular homeostasis (PMID: 38033809).