Tested Applications
| Positive WB detected in | fetal human brain tissue, Y79 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 1 publications below |
| WB | See 4 publications below |
| IF | See 1 publications below |
Product Information
29395-1-AP targets SOX11 in WB, IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag30020 Product name: Recombinant human SOX11 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 125-310 aa of NM_003108 Sequence: KMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAGATSGAGGGSR Predict reactive species |
| Full Name | SRY (sex determining region Y)-box 11 |
| Calculated Molecular Weight | 47 kDa |
| Observed Molecular Weight | 60 kDa |
| GenBank Accession Number | NM_003108 |
| Gene Symbol | SOX11 |
| Gene ID (NCBI) | 6664 |
| RRID | AB_2918291 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P35716 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
SOX11 (SRY-box transcription factor 11) is a member of the SOX (SRY-related HMG-box) family of transcription factors that plays a critical role in regulating embryonic development and cell fate determination. As a key regulator, the SOX11 protein functions by binding to specific DNA regions and coordinating with other proteins to activate genes essential for the development of the brain and nervous system. It is highly expressed during embryogenesis in various tissues, particularly the developing central and peripheral nervous system, but is largely absent in most adult differentiated tissues. Beyond its fundamental role in development, dysregulated SOX11 expression has been implicated in a wide range of diseases. It is notably associated with neurodevelopmental disorders like Coffin-Siris syndrome, where mutations in the SOX11 gene are a known cause, and plays a significant, context-dependent role in various cancers, such as mantle cell lymphoma, where its expression serves as a diagnostic and prognostic biomarker.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for SOX11 antibody 29395-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Sci Adv EIF3D safeguards the homeostasis of key signaling pathways in human primed pluripotency | ||
Stem Cells Int lncRNA CYTOR Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Modulating SOX11 via Sponging miR-6512-3p
| ||
Exp Mol Med Single-cell RNA sequencing and spatial transcriptomics of esophageal squamous cell carcinoma with lymph node metastases | ||
J Dent Sci miR-508-5p suppresses osteogenic differentiation of human periodontal ligament stem cells via targeting sex-determining region Y-related HMG-box 11 | ||
