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SPPL2A Polyclonal antibody, PBS Only

SPPL2A Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 13255-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Formulation:  PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

13255-1-PBS targets SPPL2A in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag3935

Product name: Recombinant human SPPL2A protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 361-520 aa of BC025740

Sequence: ITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ

Predict reactive species
Full Name signal peptide peptidase-like 2A
Calculated Molecular Weight 520 aa, 58 kDa
Observed Molecular Weight 58 kDa
GenBank Accession NumberBC025740
Gene Symbol SPPL2A
Gene ID (NCBI) 84888
RRIDAB_2195000
Conjugate Unconjugated
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8TCT8
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

SPPL2A(Signal peptide peptidase-like 2A) is also named as IMP3(Intramembrane protease 3), PSL2(Presenilin-like protein 2) and belongs to the peptidase A22B family. It is an aspartyl intramembrane protease, has been implicated in the proteolysis of TNF-alpha, Fas Ligand and Bri2 and endogenous signal-peptide-peptidase-like2A (SPPL2a) is localised in lysosomes/late endosomes(PMID:21896273). This protein has a signal peptide with 25 amino acid and seven glycosylation sites.

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