STAT5B Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12071-1-AP

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Freight/Packing

Con: 21 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, multi-cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human lung cancer tissue,human breast cancer tissue, human cervical cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
signal transducer and activator of transcription 5B

Calculated molecular weight:
787aa,90 kDa

Observed molecular weight:
90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STAT5B

Synonyms
STAT5, STAT5B
Background

STAT5B belongs to the transcription factor STAT family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B carries out a dual function: signal transduction and activation of transcription. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT5B.


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