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Stanniocalcin 2 Monoclonal antibody
Stanniocalcin 2 Monoclonal Antibody for IF, IHC, WB,ELISA
Cat no : 60063-1-Ig
|Positive WB detected in||A549 cells, HEK-293 cells, HT-29 cells, HCT 116 cells, HepG2 cells, PC-3 cells, pig brain tissue|
|Positive IHC detected in||human breast cancer tissue, human kidney tissue, human stomach cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HeLa cells|
|Western Blot (WB)||WB : 1:1000-1:6000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
60063-1-Ig targets Stanniocalcin 2 in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse, pig samples.
|Tested Reactivity||human, mouse, pig|
|Cited Reactivity||human, mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Stanniocalcin 2 fusion protein Ag0359|
|Full Name||stanniocalcin 2|
|Calculated molecular weight||33 kDa|
|Observed molecular weight||44 kDa|
|GenBank accession number||BC000658|
|Gene ID (NCBI)||8614|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Stanniocalcin (STC) is a family of secreted glycoprotein hormones that originally discovered in the corpuscles of Stannius, an endocrine gland of fish. STC1 and STC2, two homologues of STC family, are reported to involve in calcium and phosphate homeostasis. It is expressed in a wide variety of tissues such as kidney, spleen, heart, and pancreas. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. STC2 overexpression could promote tumor cell proliferation, invasion and metastasis in prostate cancer, ovarian cancer or neuroblastoma. STC2 is also vital for cytoprotective properties when exposed to ER stress and hypoxia.
Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning.
STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling.
Biochem Biophys Res Commun
The novel prognostic risk factor STC2 can regulate the occurrence and progression of osteosarcoma via the glycolytic pathway.