CoraLite®594-conjugated STK11/LKB1 Monoclonal antibody
STK11/LKB1 Monoclonal Antibody for WB
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse, Rat
Applications
WB
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
1H8E4
Cat no : CL594-66719
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | HeLa cells, HEK-293 cells, Jurkat cells |
Recommended dilution
Application | Dilution |
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Western Blot (WB) | WB : 1:500-1:1000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
CL594-66719 targets STK11/LKB1 in WB applications and shows reactivity with Human, Mouse, Rat samples.
Tested Reactivity | Human, Mouse, Rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | STK11/LKB1 fusion protein Ag13436 |
Full Name | serine/threonine kinase 11 |
Calculated Molecular Weight | 49 kDa |
Observed Molecular Weight | 45-49 kDa |
GenBank Accession Number | BC007981 |
Gene Symbol | LKB1 |
Gene ID (NCBI) | 6794 |
RRID | AB_2920027 |
Conjugate | CoraLite®594 Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
STK11(serine/threonine-protein kinase 11) is also named as LKB1, PJS, and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS). Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers. STK11 has 2 isoforms with MW of 49 kDa and 45 kDa, and can be detected as 50-54 kDa after posttranslational modification.
Protocols
Product Specific Protocols | |
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WB protocol for CL594 STK11/LKB1 antibody CL594-66719 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |