Stabilin-1 Polyclonal antibody

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• Stabilin-1 Polyclonal antibody (20663-1-AP)

Stabilin-1 Polyclonal Antibody for IHC, ELISA

Cat No. 20663-1-AP

Publications(2)

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, IF, ELISA

Synonyms

STAB1, CLEVER 1, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1, FEEL 1, FEEL1

• 

  IHC staining of human tonsillitis using 20663-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 20663-1-AP (Stabilin-1 antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human tonsillitis using 20663-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 20663-1-AP (Stabilin-1 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of rat liver using 20663-1-AP

  Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 20663-1-AP (Stabilin-1 antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of rat liver using 20663-1-AP

  Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 20663-1-AP (Stabilin-1 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of mouse spleen using 20663-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 20663-1-AP (Stabilin-1 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive IHC detected in: human tonsillitis tissue, mouse spleen tissue, rat liver tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

20663-1-AP targets Stabilin-1 in IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: stabilin 1
• Calculated Molecular Weight: 276 kDa
• GenBank Accession Number: NM_015136
• Gene Symbol: STAB1
• Gene ID (NCBI): 23166
• RRID: AB_2878721
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9NY15
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Stabilin-1, also known as FEEL-1 or CLEVER-1, is a large type I transmembrane scavenger receptor primarily expressed on tissue-resident macrophages and lymphatic sinus endothelial cells. It functions in endocytosis, intracellular sorting, phagocytosis, and cell adhesion, and is highly upregulated in alternatively activated macrophages by IL-4 and dexamethasone. The protein localizes to endosomes and the trans-Golgi network, playing essential roles in immune regulation, pathogen clearance, and tissue homeostasis. (PMID: 16989725)

Publications

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human	IF	Cell Rep Med; A spatially resolved transcriptome landscape during thyroid cancer progression; Authors - Tian Liao
human	IHC	J Inflamm Res; Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients; Authors - Tao Wang