Anti-Human TGFBR2 Rabbit Recombinant Antibody, PBS Only

• 

  FC experiment of human PBMCs using 98438-1-RR (same clone as 98438-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human TGFBR2 Rabbit RecAb (98438-1-RR, Clone: 250238A7) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD3. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98438-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98438-1-RR (same clone as 98438-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human TGFBR2 Rabbit RecAb (98438-1-RR, Clone: 250238A7) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98438-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human peripheral blood leukocytes using 98438-1-RR (same clone as 98438-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human TGFBR2 Rabbit RecAb (98438-1-RR, Clone: 250238A7) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98438-1-PBS in a different storage buffer formulation.

TGFBR2 Recombinant Antibody for FC

Cat No. 98438-1-PBS

Clone No.250238A7

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

EC:2.7.11.30, TbetaR-II, TGF beta receptor type 2, TGF-beta receptor type II, TGF-beta receptor type-2

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Product Information

98438-1-PBS targets TGFBR2 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TGFBR2 fusion protein Eg2943
• Full Name: transforming growth factor, beta receptor II (70/80kDa)
• Calculated Molecular Weight: 65 kDa
• GenBank Accession Number: NM_003242.5
• Gene Symbol: TGFBR2
• Gene ID (NCBI): 7048
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P37173-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

TGF beta Receptor II (TGFBR2) is a member of the transforming growth factor-β (TGF-β) superfamily, which are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (PMID: 10974075). TGFBR2 is a serine/threonine kinase and the primary ligand-binding receptor. After binding of the ligand TGF-β1, TGFBR2 forms a heterodimer complex with TGFBR1, causing conformational changes and signal propagation via canonical (SMAD-dependent) and non-canonical (SMAD-independent) routes. Upon translocation into the nucleus, activated SMAD complexes can interact with various transcription factors to control target gene expression (PMID: 31454892).