TGFBR3-Specific Polyclonal antibody, PBS Only

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• TGFBR3-Specific Polyclonal antibody, PBS Only (20000-1-PBS)

• 

  WB analysis of A549 using 20000-1-AP (same clone as 20000-1-PBS)

  A549 cells were subjected to SDS PAGE followed by western blot with 20000-1-AP (TGFBR3-Specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20000-1-PBS in a different storage buffer formulation.

• 

  WB analysis of A431 using 20000-1-AP (same clone as 20000-1-PBS)

  A431 cells were subjected to SDS PAGE followed by western blot with 20000-1-AP (TGFBR3-Specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20000-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

TGFBR3-Specific Polyclonal Antibody for WB, Indirect ELISA

Cat No. 20000-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

TGFBR3, betaglycan, BGCAN, TGF beta receptor type 3, TGF beta receptor type III

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Product Information

20000-1-PBS targets TGFBR3-Specific in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: transforming growth factor, beta receptor III
• Calculated Molecular Weight: 93 kDa
• Observed Molecular Weight: 110-150 kDa
• GenBank Accession Number: NM_003243
• Gene Symbol: TGFBR3
• Gene ID (NCBI): 7049
• RRID: AB_10664930
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q03167
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106). This antibody is specific to TGFBR3.