TINP1 Polyclonal antibody, PBS Only

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• TINP1 Polyclonal antibody, PBS Only (16230-1-PBS)

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  WB analysis using 16230-1-AP (same clone as 16230-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16230-1-AP (TINP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16230-1-PBS in a different storage buffer formulation.

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  WB analysis of Caco-2 using 16230-1-AP (same clone as 16230-1-PBS)

  Caco-2 cells were subjected to SDS PAGE followed by western blot with 16230-1-AP (TINP1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16230-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 16230-1-AP (same clone as 16230-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 16230-1-AP (TINP1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16230-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 16230-1-AP (same clone as 16230-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 16230-1-AP (TINP1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16230-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 16230-1-AP (same clone as 16230-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16230-1-AP (TINP1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16230-1-PBS in a different storage buffer formulation.

TINP1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 16230-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

HUSSY-29, HUSSY29, HCL G1, Hairy cell leukemia protein 1, Hairy cell leukemia

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Product Information

16230-1-PBS targets TINP1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag8822

  Product name: Recombinant human TINP1 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 1-260 aa of BC005288

  Sequence: MPQNEYIELHRKRYGYRLDYHEKKRKKESREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV

• Full Name: TGF beta-inducible nuclear protein 1
• Calculated Molecular Weight: 260 aa, 30 kDa
• Observed Molecular Weight: 30 kDa
• GenBank Accession Number: BC005288
• Gene Symbol: TINP1
• Gene ID (NCBI): 10412
• RRID: AB_2878232
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O95478
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

TINP1 (TGF beta inducible nuclear protein 1) was widely expressed in various cell lines. TINP1 overexpression significantly promoted tumor cell proliferation, which may be associated with the downregulation of p53 expression. Furthermore, TINP1 promoted a number of cell lines to the S phase of the cell cycle. TINP1 promotes cell proliferation and significantly reduces p53 and p21 expression.