TIPRL Polyclonal antibody

TIPRL Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 15933-1-AP

Synonyms

TIP, TIP41, TIP41 like protein, TIPRL, Type 2A interacting protein

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Validation Data Gallery

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  WB analysis using 15933-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 15933-1-AP (TIPRL antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse brain tissue, mouse kidney tissue, rat brain tissue, rat kidney tissue

Recommended dilution

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

15933-1-AP targets TIPRL in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: TIPRL fusion protein Ag8780
• Full Name: TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
• Calculated Molecular Weight: 178 aa, 20 kDa
• Observed Molecular Weight: 33 kDa
• GenBank Accession Number: BC009506
• Gene Symbol: TIPRL
• Gene ID (NCBI): 261726
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TIPRL, also known as TIP, TIP4, is an inhibitory regulator of protein phosphatase-2A (PP2A) , PP4, and PP6(PMID: 17384681). TIPRL, an evolutionarily conserved protein, plays a critical role in mediating γ-H2AX signal transduction upon DNA damage(PMID: 26717153).