Tested Applications
| Positive IHC detected in | human spleen tissue, human small intestine tissue, human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
19816-1-AP targets TLR1 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag13852 Product name: Recombinant human TLR1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 604-786 aa of BC109093 Sequence: LDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK Predict reactive species |
| Full Name | toll-like receptor 1 |
| Calculated Molecular Weight | 786 aa, 90 kDa |
| GenBank Accession Number | BC109093 |
| Gene Symbol | TLR1 |
| Gene ID (NCBI) | 7096 |
| RRID | AB_2878610 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q15399 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Toll-Like Receptor 1 (TLR1), a member of the Toll-like receptor (TLR) family, is a type I transmembrane glycoprotein. TLR1 forming a heterodimer with TLR2 is located on the cell surface and is essential for the innate immune response to a variety of microbial component.
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for TLR1 antibody 19816-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The TLR1 Polyclonal antibody (Cat# 19816-1-AP) has 8 total citations across journals including Signal Transduction and Targeted Therapy, Pharmacological Research, International Journal of Biological Macromolecules, Molecular Neurobiology, Bioorganic Chemistry, Infection and Immunity, and Annals of Diagnostic Pathology. Research fields span HPV-related cervical immunotherapy, thrombopoiesis, breast cancer tumor microenvironment, Alzheimer's neuroinflammation, TLR2/6 immunostimulant development, bacterial infection (Pasteurella multocida), and placental infectious disease.
| Species | Application | Title |
|---|---|---|
Signal Transduct Target Ther Innovative peptide-loaded hybrid membrane nanovaccine enables precise personalized immunotherapy for HPV-related cervical diseases. | ||
Pharmacol Res Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin. | ||
Int J Biol Macromol Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment.
| ||
Mol Neurobiol Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer's Disease | ||
Bioorg Chem Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants | ||
Infect Immun Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2 |
